No. 67 Defining a mechanism of the enhancement of bioavailability of astaxanthin by γ-cyclodextrin
This research was reported in 31th Cyclodextrin Symposium (Shimane, Sep. 11~12, 2014).
Our company have attractive technologies in functional food and personal care fields which raise the water solubility, stability and bioavailability of a functional ingredient by using the inclusion property of cyclodextrin (CD).
Recently, we focused "Astaxanthin" as a notable anti-aging ingredient and succeeded in the dramatic enhancement of its stability, antioxidant capacity, bioavailability and swimming endurance by inclusion with γ-CD (* please refer to the newest result of research "8th" and the "48th" of our homepage for details.). We believe those results showed that "Astaxanthin-γ-CD complex" is useful as functional health food and cosmetics materials.
In this research, aqueous solubility of astaxanthin with γ-CD in artificial intestinal juice was examined in order to clarify the mechanism of the enhanced bioavailability.
Structure of Axtaxanthin
Heralth benefits of astaxanthin
Anti-oxidant effect / Improving of brain functions / Anti-eyestrain effect / Anti-arteriosclerotic effect / Anti-inflammatory effect / Improving of skin conditions
Artificial intestinal juice (FeSSIF)
In this study, FeSSIF wihtout sodium taurocholate and lecithin was also used as blank buffer.
Result : Aqueous solubility of astaxanthin in FeSSIF
Significantly enhancement of aqueous solubility of Ax with γ-CD was observed in the case of FeSSIF.
Enhanced bioavailability of astaxanthin by γ-CD is caused by effective solubilization of astaxanthin from γ-CD complex in intestinal juice similar to coenzymeQ10-γ-CD and curcumin-γ-CD.