シクロデキストリン論文データベース検索システム
| 論文名 | [Determination of enantiomeric impurity in levocetirizine tablets by capillary electrophoresis]. |
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| 著者 | Shi-zhuo Wang Yun-feng Zhao Jia-yi Sun Xing-jie Guo |
| キーワード | |
| 出版年月 | 1970年1月 |
| 発表先 | Zhejiang Da Xue Xue Bao Yi Xue Ban. 2014 Mar;43(2):150-4. |
| WEBサイト | |
| 論文概要（和文） | キャピラリー電気泳動によるレボセチリジン錠剤中の鏡像異性不純物の定量 |
| 論文概要（英文） | Objective: To determine enantiomeric impurity in levocetirizine tablets by using capillary electrophoresis. Methods: The effects of pH and the concentrations of sulfated-Β-cyclodextrin (S-Β-CD) and buffer salt on chiral resolution were examined with S-Β-CD as chiral selector. Results: A good enantioseparation of cetirizine was achieved with 30 mmol/L NaH2PO4 buffer solution (pH 7.0) containing 20 g/L of S-Β-CD. Conclusion: The method developed in the study is sensitive and reliable for determination of enantiomeric impurity in levocetirizine tablets. |