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| 論文名 | [Determination of R(-)- isomer in repaglinide tablets by capillary electrophoresis]. |
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| 著者 | Xiao-wei Yuan Jia-yi Sun Shi-zhuo Wang Xing-jie Guo |
| キーワード | |
| 出版年月 | 1970年1月 |
| 発表先 | Zhejiang Da Xue Xue Bao Yi Xue Ban. 2014 Mar;43(2):145-9. |
| WEBサイト | |
| 論文概要（和文） | キャピラリー電気泳動によるレパグリニド錠剤中のR（-）-異性体の測定 |
| 論文概要（英文） | Objective: To develop a capillary electrophoresis system for enantiomeric impurity test of repaglinide. Methods: An uncoated fused silica capillary (50 μm×50 cm, with an effective length of 41 cm) was used. The running buffer was composed of 30 mmol/L NaH2PO4 and 5 mg/ml carboxymethyl-β-cyclodextrin(pH 3.5). Results: Linear range was 2.00-80.00 μg/ml (correlation coefficient was 0.9993). The average recovery rate was 92.5% to 105.0%. Conclusion: The method is simple, accurate and sensitive and it can be used for determination of enantiomeric impurities in repaglinide tablet. |