| 論文名 |
[Investigation of properties of the resveratrol-beta-cyclodextrin inclusion complex by drug-protein interaction spectra and molecular modeling]. |
| 著者 |
Ming Guo
Min-Zhong Zhan
Yan-Ke Jiang
|
| キーワード |
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| 出版年月 |
1970年1月 |
| 発表先 |
Yao Xue Xue Bao. 2014 May;49(5):726-33. |
| WEBサイト |
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| 論文概要（和文） |
薬物-タンパク質相互作用スペクトルおよび分子モデリングによるレスベラトロール-ベータ-シクロデキストリン包接複合体の特性の調査 |
| 論文概要（英文） |
The supramolecular inclusion properties of beta-cyclodextrin (beta-CD) and resveratrol (Res) were investigated using drug-protein interaction spectroscopy method. The differences between the results of interaction spectroscopy method and the results of classical method were compared. The total energy of the stable inclusion of cyclodextrin-resveratrol was calculated by Gaussian theory calculation. The stable inclusions in the process of interaction between resveratrol/inclusion complex and bovine lactgoferrin (BLF) were studied by molecular modeling. The results showed that the interaction spectroscopy method could explain the property of the inclusion in a more sensitive manner, it also interpreted the conveying mechanism of BLF binding with inclusion complex. The molecular modeling result showed consistent results with Gaussian theory calculation; both of the two methods obtained the stable configuration of beta-CD-Res inclusion. The relevant result provided an experimental consequence for the pharmacology research of beta-cyclodextrin-resveratrol inclusion complex as well as offering a new reference to the future research of supramolecular inclusion compound. |
