| 論文名 |
1H NMR studies of binary and ternary dapsone supramolecular complexes with different drug carriers: EPC liposome, SBE-β-CD and β-CD. |
| 著者 |
Lucas Martins
Monica Arrais
Alexandre de Souza
Anita Marsaioli
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| キーワード |
|
| 出版年月 |
1970年1月 |
| 発表先 |
Magn Reson Chem. 2014 Nov;52(11):665-72. doi: 10.1002/mrc.4087. Epub 2014 Jul 14. |
| WEBサイト |
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| 論文概要（和文） |
異なる薬物担体との二元および三元ダプソン超分子複合体の1 H NMR研究：EPCリポソーム、SBE-β-CDおよびβ-CD |
| 論文概要（英文） |
Binary and ternary systems composed of dapsone, sulfobutylether-β-cyclodextrin (SBE-β-CD), β-CD and egg phosphatidylcholine (EPC) were evaluated using 1D ROESY, saturation transfer difference NMR and diffusion experiments (DOSY) revealing the binary complexes Dap/β-CD (K(a) 1396 l mol(-1)), Dap/SBE-β-CD (K(a) 246 l mol(-1)), Dap/EPC (K(a) 84 l mol(-1)) and the ternary complex Dap/β-CD/EPC (K(a) 18 l mol(-1)) in which dapsone is more soluble. |
