| 論文名 |
6-Triazolyl-6-deoxy-β-cyclodextrin derivatives: synthesis, cellular toxicity, and phase-solubility study. |
| 著者 |
Hoa Thi Le
Hyun Mi Jeon
Choon Woo Lim
Tae Woo Kim
|
| キーワード |
|
| 出版年月 |
1970年1月 |
| 発表先 |
Carbohydr Res. 2014 Jun 4;391:22-8. doi: 10.1016/j.carres.2014.03.020. Epub 2014 Mar 28. |
| WEBサイト |
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| 論文概要（和文） |
6-トリアゾリル-6-デオキシ-β-シクロデキストリン誘導体：合成、細胞毒性、および相溶解度研究 |
| 論文概要（英文） |
Heptakis{6-(4-hydroxymethyl-1H-[1,2,3]triazol-1-yl)-6-deoxy}-β-cyclodextrin (HTβCD) and heptakis{6-(4-sulfonylmethyl-1H-[1,2,3]triazol-1-yl)-6-deoxy}-β-cyclodextrin (STβCD) were prepared using copper(I)-catalyzed azide-alkyne cycloaddition between 6-azido-6-deoxy-β-CD and one of two alkynes, propargyl alcohol, and sodium propargyl sulfonate, respectively. The structures of HTβCD and STβCD were characterized by NMR techniques. NMR interpretations and computer modeling suggested that the limited freedom of rotation of the triazole moieties keeps HTβCD and STβCD rigid and compact. Water solubility tests of HTβCD and STβCD showed that the minimum water solubility of HTβCD and STβCD is at least 20times higher than that of β-CD. MTT assay showed that HTβCD and STβCD did not influence the cell viability under 1mM. A phase-solubility study of prednisolone with the CD derivatives showed increased solubility of prednisolone in the presence of increasing concentrations of HTβCD and STβCD. |
