| 論文名 |
A temporary decrease in twitch response following reversal of rocuronium-induced neuromuscular block with a small dose of sugammadex in a pediatric patient. |
| 著者 |
Hajime Iwasaki
Kenichi Takahoko
Shigeaki Otomo
Tomoki Sasakawa
Takayuki Kunisawa
Hiroshi Iwasaki
|
| キーワード |
|
| 出版年月 |
1970年1月 |
| 発表先 |
J Anesth. 2014 Apr;28(2):288-90. doi: 10.1007/s00540-013-1688-3. Epub 2013 Aug 21. |
| WEBサイト |
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| 論文概要（和文） |
小児患者におけるスクロマデックスの少量投与によるロクロニウム誘発神経筋遮断の逆転後の単収縮反応の一時的な減少 |
| 論文概要（英文） |
We report a temporary decrease in twitch response following reversal of rocuronium-induced neuromuscular block with a small dose of sugammadex in our dose-finding study in pediatric patients. A 19-month-old female infant (9.6 kg, 80 cm) was scheduled for elective cheiloplasty surgery. Anesthesia was induced with nitrous oxide 50% and sevoflurane 5% and maintained with air, oxygen, sevoflurane 3%, and fentanyl (total, 3 μg/kg). Neuromuscular monitoring was performed at the adductor pollicis muscle after induction of anesthesia but before the administration of rocuronium. Total dose of rocuronium during the surgery was 0.9 mg/kg. Neuromuscular block was reversed with 0.5 mg/kg sugammadex when one response was observed with post-tetanic count stimulation. Twitch responses after sugammadex administration showed a temporary decrease after its initial recovery. Maximum decreases in twitch responses were observed 17 min after initial dose of sugammadex. Twitch responses recovered to their control values after additional doses of 3.5 mg/kg sugammadex (4 mg/kg in total). Time from sugammadex administration to maximum decreases in twitch responses is earlier than has been reported in adults (20-70 min). It is demonstrated that following neuromuscular block reversal with insufficient dose of sugammadex, there is a possibility of the recurrence of residual paralysis within less than 20 min in pediatric patients. |
