| 論文名 |
Antibacterial phototoxic effects of synthetic asymmetric and glycosylated curcuminoids in aqueous formulations: studies on curcumin and curcuminoids. LIV. |
| 著者 |
Marianne Lilletvedt Tovsen
Ellen Bruzell
Erika Ferrari
Monica Saladini
Vivek S Gaware
M?r M?sson
Solveig Kristensen
Hanne Hjorth T?nnesen
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| キーワード |
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| 出版年月 |
1970年1月 |
| 発表先 |
J Photochem Photobiol B. 2014 Nov;140:150-6. |
| WEBサイト |
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| 論文概要（和文） |
水性製剤における合成非対称およびグリコシル化クルクミノイドの抗菌光毒性効果クルクミンおよびクルクミノイドに関する研究 LIV |
| 論文概要（英文） |
The aim of this study was to evaluate the in vitro phototoxic potential of synthetic asymmetric and glycosylated curcuminoids on planktonic model bacteria by counting the colony forming units. The Gram-positive Enterococcus faecalis and the Gram-negative Escherichia coli were exposed to aqueous solutions of the curcuminoids (?2.5 μM) in the presence or absence of selected pharmaceutical excipients (Pluronic F127, PEG 400 and HPγCD) in combination with a low irradiation dose (5 J/cm(2); λmax: 450 nm) of constant irradiance and time. All the asymmetric curcuminoids, but only one of the glycosylated curcuminoids demonstrated substantial phototoxic effect on E.faecalis (?4.7 log reduction). Only two of the asymmetric curcuminoids showed a moderate to low phototoxic effect on the more persistent E.coli. This study emphasized that aromatic hydroxyl substituents in the para-position are important to maintain the phototoxic potential of curcuminoids independent of molecular symmetry. Glycosylation of the aromatic substituents resulted in a substantial loss in phototoxicity towards planktonic bacteria, an apparent change in the non-radiative S?-decay process and a weaker interaction with Pluronic F127 compared to the non-glycosylated curcuminoids. The selected excipients Pluronic F127, PEG 400 and HPγCD strongly influenced the phototoxic potential of the unsymmetrical, non-glycosylated compounds. |
