| 論文名 |
[Study on solubilization effect of solid dispersion technology and inclusion technology on pulsatillae total saponins]. |
| 著者 |
Yong-Mei Guan
Ni Zhang
Zhen-Hua Chen
Hong-Ning Liu
Wei-Feng Zhu
Li-Hua Chen
Ming Yang
|
| キーワード |
|
| 出版年月 |
1970年1月 |
| 発表先 |
Zhongguo Zhong Yao Za Zhi. 2013 Dec;38(23):4061-6. |
| WEBサイト |
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| 論文概要（和文） |
[Pulsatillae総サポニンに対する固体分散技術と封入技術の可溶化効果に関する研究]。 |
| 論文概要（英文） |
Objective: To study the effect of solid dispersion technology and inclusion technology on dissolution performance of Pulsatillae total saponins, and preliminarily investigate its mechanism. Method: The solid dispersion of Pulsatillae total saponins-PEG 4000 was prepared by the melting method. The inclusion compound of Pulsatillae total saponins-hydroxypropyl-beta-cyclodextrin ( HP-beta-CD) was prepared by the freeze-drying method. The properties of solid dispersion and inclusion compound were identified by using IR, DSC and NMR. And the dissolution of solid dispersion and inclusion compound were also determined by the small glass method. Result: IR, DSC and NMR results showed the formation of solid dispersion and inclusion compound. In terms of the dissolution, the inclusion compound ranked first, which was followed by solid dispersion and bulk pharmaceutical chemicals. Conclusion: The inclusion technology could significantly increase the dissolution of Pulsatillae total saponins, whereas the solid dispersion showed no notable solubilization effect. |
