| 論文名 |
A multifunctional bichromophoric nanoaggregate for fluorescence imaging and simultaneous photogeneration of RNOS and ROS. |
| 著者 |
Aurore Fraix
A Ricardo Gon?alves
Venera Cardile
Adriana C E Graziano
Theodossis A Theodossiou
Konstantina Yannakopoulou
Salvatore Sortino
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| キーワード |
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| 出版年月 |
1970年1月 |
| 発表先 |
Chem Asian J. 2013 Nov;8(11):2634-41. |
| WEBサイト |
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| 論文概要（和文） |
蛍光イメージングおよびRNOSとROSの同時光生成のための多機能二色性ナノ凝集体。 |
| 論文概要（英文） |
We report the design, preparation, and properties of a nanoaggregate formed in phosphate buffer solution by a porphyrin-β-cyclodextrin (β-CD) conjugate and a nitric oxide photodonor tailored to fit the β-CD cavity. The small nanoassembly with a diameter of about 13 nm exhibits the typical red fluorescence of the porphyrin chromophore. The empty cavity of the β-CD unit in the nanoaggregate is able to accommodate the NO photodonor, thereby forming a supramolecular bichromophoric aggregate with diameter of about 16 nm. This nanoconstruct preserves the fluorescence of the porphyrin core and is able to generate nitric oxide and singlet oxygen under illumination with visible light. The nanoassembly internalizes in melanoma cells, can be mapped therein by fluorescence microscopy, and induces a significant level of cell mortality, probably due to the combined action of reactive nitrogen oxide species (RNOS) and reactive oxygen species (ROS). |
