| 論文名 |
A randomized, double-blind, placebo-controlled study to test the efficacy of topical 2-hydroxypropyl-Beta-cyclodextrin in the prophylaxis of recurrent herpes labialis. |
| 著者 |
Gabriela Senti
Reto Iannaccone
Nicole Graf
Manuela Felder
Fabian Tay
Thomas K?ndig
|
| キーワード |
|
| 出版年月 |
1970年1月 |
| 発表先 |
Dermatology. 2013;226(3):247-52. |
| WEBサイト |
|
| 論文概要（和文） |
再発性口唇ヘルペスの予防における局所2-ヒドロキシプロピル-ベータ-シクロデキストリンの有効性を試験するための無作為化二重盲検プラセボ対照試験。 |
| 論文概要（英文） |
Herpes labialis affects one third of the population. We evaluated the topical application of an antiviral compound, hydroxypropyl-β-cyclodextrin (2-HPβCD), in reducing herpes labialis relapses. In this double-blind, randomized, placebo-controlled trial, 40 patients were randomized to a polyethylene glycol (PEG) formulation containing 20% 2-HPβCD or to a vehicle control arm. The gel was applied to the lips twice daily for 6 months. The primary objective was reducing herpes relapses. Surprisingly, the drug group had significantly more relapses than the vehicle group (p = 0.003). While the median numbers of relapses in the preceding year were 12 in the vehicle group and 10 in the drug group, both groups experienced very few relapses during the 6-month treatment period, with a median of 0 in the vehicle group and a median of 2 in the drug group. The impressive reduction of relapses in both groups may be due to a placebo effect or due to the topical treatment with PEG. |
