| 論文名 |
Amphiphilic oligoethyleneimine-β-cyclodextrin "click" clusters for enhanced DNA delivery. |
| 著者 |
?lvaro Mart?nez
C?line Bienvenu
Jos? L Jim?nez Blanco
Pierre Vierling
Carmen Ortiz Mellet
Jos? M Garc?a Fern?ndez
Christophe Di Giorgio
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| キーワード |
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| 出版年月 |
1970年1月 |
| 発表先 |
J Org Chem. 2013 Aug 16;78(16):8143-8. |
| WEBサイト |
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| 論文概要（和文） |
両親媒性オリゴエチレンイミン-β-シクロデキストリン「クリック」クラスターによるDNA送達の強化。 |
| 論文概要（英文） |
Monodisperse amphiphilic oligoethyleneimine (OEI)-β-cyclodextrin (βCD) clusters have been prepared, and their potential as gene delivery systems has been evaluated in comparison with a nonamphiphilic congener. The general prototype incorporates tetraethyleneimine segments linked to the primary rim of βCD through either triazolyl or thioureidocysteaminyl connectors. Transfection efficiency data for the corresponding CD:pDNA nanocomplexes (CDplexes) in BNL-CL2 murine hepatocytes evidenced the strong beneficial effect of facial amphiphilicity. |
