| 論文名 |
Analysis of the effect of a 2-(trifluoromethyl)-1H-benzimidazole derivative on Trichinella spiralis muscle larvae. |
| 著者 |
F?lix Matadamas-Mart?nez
Benjam?n Nogueda-Torres
Alicia Hern?ndez-Campos
Francisco Hern?ndez-Luis
Rafael Castillo
Guillermo Mendoza
Javier R Ambrosio
Gabriela Andr?s-Antonio
Lili?n Y?pez-Mulia
|
| キーワード |
|
| 出版年月 |
1970年1月 |
| 発表先 |
Vet Parasitol. 2013 May 20;194(2-4):193-7. |
| WEBサイト |
|
| 論文概要（和文） |
2-（トリフルオロメチル）-1H-ベンズイミダゾール誘導体の旋毛虫の幼虫に対する効果の分析。 |
| 論文概要（英文） |
Albendazole and mebendazole are widely used in the treatment of trichinellosis; however, chemotherapy failure has been reported. In an effort to develop new anthelminthic compounds, we examined a previously synthesized 2-(trifluoromethyl)-1H-benzimidazole derivative (1) that showed good in vitro activity against Trichinella spiralis muscle larvae but low in vivo efficacy. In order to improve the solubility of compound 1, an inclusion complex with 2-hydroxypropyl-β-cyclodextrin (1/HP-βCD) was prepared. When 1/HP-βCD was tested in vivo, it significantly reduced the ML burden (84%). In addition, a proteomic analysis of T. spiralis ML treated with 1 revealed significant changes in the expression levels of proteins involved in energy metabolism and the cytoskeleton of the parasite. Compound (1) also induced extensive ultrastructural changes in the cuticle, hypodermis and midgut of the parasite. |
