| 論文名 |
Axonal translation of β-catenin regulates synaptic vesicle dynamics. |
| 著者 |
Anne Marion Taylor
Jason Wu
Hwan-Ching Tai
Erin M Schuman
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| キーワード |
|
| 出版年月 |
1970年1月 |
| 発表先 |
J Neurosci. 2013 Mar 27;33(13):5584-9. |
| WEBサイト |
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| 論文概要（和文） |
β-カテニンの軸索翻訳はシナプス小胞ダイナミクスを調節する。 |
| 論文概要（英文） |
Many presynaptic transcripts have been observed in axons, yet their role in synapse development remains unknown. Using visually and pharmacologically isolated presynaptic terminals from dissociated rat hippocampal neurons, we found that ribosomes and β-catenin mRNA preferentially localize to recently formed boutons. Locally translated β-catenin accumulates at presynaptic terminals, where it regulates synaptic vesicle release dynamics. Thus, local translation of β-catenin is a newly described mechanism for axons to independently functionalize nerve terminals at great distances from cellular somata. |
