| 論文名 |
Build-up of an antimicrobial multilayer coating on a textile support based on a methylene blue-poly(cyclodextrin) complex. |
| 著者 |
Adeline Martin
Nicolas Tabary
Feng Chai
Laurent Leclercq
Jatupol Junthip
Fran?ois Aubert-Viard
Christel Neut
Marek Weltrowski
Nicolas Blanchemain
Bernard Martel
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| キーワード |
|
| 出版年月 |
1970年1月 |
| 発表先 |
Biomed Mater. 2013 Dec;8(6):065006. |
| WEBサイト |
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| 論文概要（和文） |
メチレンブルーポリ（シクロデキストリン）複合体に基づくテキスタイルサポート上の抗菌多層コーティングのビルドアップ。 |
| 論文概要（英文） |
The aim of this work was to develop an antibacterial multilayer coating activated with methylene blue (MB) and based on chitosan (CHT) and cyclodextrin polyelectrolyte (polyCD) onto a non-woven polyethylene terephthalate (PET) textile support. The MB-free and MB-loaded systems were built-up by applying the dip-coating technique, alternating soak cycles of the PET textile preliminarily modified with carboxylate groups in CHT and in polyCD or polyCD/MB complex solutions. The layer-by-layer assembly build-up was followed by optical waveguide lightmode spectroscopy on the one hand and by gravimetry once it was applied on the textile substrate on the other hand. Two chitosan grades were used, low molecular weight (CHT-L) and medium molecular weight (CHT-M). The influence of the molar ratio CD/MB in the polyCD solutions was varied and finally the system underwent a post reticulation with genipin. Such parameters influences were investigated with regard to the loading capacity in MB of the systems, the release kinetics profiles of MB in pure water, phosphate buffer and MEM media, and the degradation of the self-assembled coating in the same media. Finally, biological and microbiological tests were performed to demonstrate the cytocompatibility of the systems and their ability to display a sustained antibacterial effect of the device through the MB prolonged release. |
