| 論文名 |
Cholesterol metabolism-associated molecules in late onset Alzheimer's disease. |
| 著者 |
M T Fiorenza
A Dardis
S Canterini
R P Erickson
|
| キーワード |
|
| 出版年月 |
1970年1月 |
| 発表先 |
J Biol Regul Homeost Agents. Apr-Jun 2013;27(2 Suppl):23-35. |
| WEBサイト |
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| 論文概要（和文） |
遅発性アルツハイマー病におけるコレステロール代謝関連分子。 |
| 論文概要（英文） |
Alzheimer痴 disease (AD) is the most common cause of dementia and, with an aging population, poses a huge public health problem. Although a small per cent is caused by single gene changes, most AD is sporadic and unexplained. Of many modifying factors, changes in brain cholesterol homeostasis are the best studied. We present a review of the role of altered cholesterol metabolism and hypercholesterolemia in APP processing and Abeta generation. We also provide an overview of the potential pharmacological modulation of cholesterol homeostasis in the brain by cholesterol-lowering agents and beta-cyclodextrins. |
