| 論文名 |
Cyclodextrin complexed [60]fullerene derivatives with high levels of photodynamic activity by long wavelength excitation. |
| 著者 |
Atsushi Ikeda
Tatsuya Iizuka
Naotake Maekubo
Ryota Aono
Jun-Ichi Kikuchi
Motofusa Akiyama
Toshifumi Konishi
Takuya Ogawa
Norihiro Ishida-Kitagawa
Hisashi Tatebe
Kazuhiro Shiozaki
|
| キーワード |
|
| 出版年月 |
1970年1月 |
| 発表先 |
ACS Med Chem Lett. 2013 Jun 18;4(8):752-6. |
| WEBサイト |
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| 論文概要（和文） |
長波長励起による高レベルの光線力学的活性を有するシクロデキストリン錯体化[60]フラーレン誘導体。 |
| 論文概要（英文） |
We have evaluated the photodynamic activities of C60 derivative?γ-cyclodextrin (γ-CDx) complexes and demonstrated that they were significantly higher than those of the pristine C60 and C70?γ-CDx complexes under photoirradiation at long wavelengths (610-720 nm), which represent the optimal wavelengths for photodynamic therapy (PDT). In particular, the cationic C60 derivative?γ-CDx complex had the highest photodynamic ability because the complex possessed the ability to generate high levels of (1)O2 and provided a higher level of intracellular uptake. The photodynamic activity of this complex was greater than that of photofrin, which is the most widely used of the known clinical photosensitizers. These findings therefore provide a significant level of information toward the optimization of molecular design strategies for the synthesis of fullerene derivatives for PDT. |
