| 論文名 |
Cyclodextrin-based nanocomplexes for sustained delivery of human growth hormone. |
| 著者 |
Maharajan Sivasubramanian
Joon-Youl Lee
Kap Jin Kim
Gurusamy Saravanakumar
Young Mo Kang
Jae Hyung Park
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| キーワード |
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| 出版年月 |
1970年1月 |
| 発表先 |
J Nanosci Nanotechnol. 2013 Nov;13(11):7306-11. |
| WEBサイト |
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| 論文概要（和文） |
人間の成長ホルモンの持続的な配信のためのシクロデキストリンベースのナノ複合体。 |
| 論文概要（英文） |
The use of human growth hormone (hGH) as a therapeutic protein has been limited by its instability in biological fluids and short biological half-life in vivo. In this study, glycol chitosan (GC) bearing beta-cyclodextrin (GC-betaCD) as the carrier of hGH was synthesized by the covalent attachment of a carboxymethyl derivative of betaCD to the GC backbone via amide bond formation. The GC-betaCD conjugate could form self-assembled nanoparticles (340 nm in mean diameter) in an aqueous solution, resulting from hydrogen bonding among betaCDs at the backbone of the conjugate. hGH was effectively encapsulated into the nanoparticles because of hydrophobic interactions between the hydrophobic cavity of betaCD and alkyl or aromatic groups of amino acids in hGH. From the in vitro release experiments, it was found that the nanoparticles released hGH in a sustained manner for 9 days. Overall, the GC-betaCD conjugate might be a promising carrier for sustained delivery of hGH. |
