| 論文名 |
Cyclodextrin-based nanosponges: effective nanocarrier for tamoxifen delivery. |
| 著者 |
Satyen Torne
Sharad Darandale
Pradeep Vavia
Francesco Trotta
Roberta Cavalli
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| キーワード |
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| 出版年月 |
1970年1月 |
| 発表先 |
Pharm Dev Technol. May-Jun 2013;18(3):619-25. |
| WEBサイト |
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| 論文概要（和文） |
シクロデキストリンベースのナノスポンジ：タモキシフェン配信のための効果的なナノキャリア。 |
| 論文概要（英文） |
The purpose of the present study was to develop Tamoxifen loaded β-cyclodextrin nanosponges for oral drug delivery. The three types of Tamoxifen loaded β-cyclodextrin nanosponges were synthesized by varying the molar ratios of β-cyclodextrin to carbonyldiimidazole as a crosslinker viz. 1:2, 1:4 and 1:8. The Tamoxifen nanosponge complex (TNC) with particle size of 400-600 nm was obtained by freeze drying method. Differential scanning calorimetry, Fourier transformed infra-red spectroscopy and X-ray powder diffraction studies confirmed the complexation of Tamoxifen with cyclodextrin nanosponge. AUC and Cmax of TNC formulation (1236.4 ± 16.12 ?g ? mL(-1) h, 421.156 ± 0.91 ?g/mL) after gastric intubation were 1.44 fold and 1.38 fold higher than plain drug (856.079 ± 15.18 ?g ? mL(-1) h, 298.532 ± 1.15 ?g/mL). Cytotoxic studies on MCF-7 cells showed that TNC formulation was more cytotoxic than plain Tamoxifen after 24 and 48 h of incubation. |
