| 論文名 |
Cyclodextrin-derived pH-responsive nanoparticles for delivery of paclitaxel. |
| 著者 |
Hongmei He
Sha Chen
Jianzhi Zhou
Yin Dou
Liu Song
Ling Che
Xing Zhou
Xin Chen
Yi Jia
Jianxiang Zhang
Shuhui Li
Xiaohui Li
|
| キーワード |
|
| 出版年月 |
1970年1月 |
| 発表先 |
Biomaterials. 2013 Jul;34(21):5344-58. |
| WEBサイト |
|
| 論文概要（和文） |
パクリタキセルの送達のためのシクロデキストリン由来のpH応答性ナノ粒子。 |
| 論文概要（英文） |
Engineering of pH-responsive nanoplatforms can be facilely achieved from acetalated α-cyclodextrin materials. The hydrolysis period of nanoparticles can be precisely tailored by using materials with various acetal types that can be easily controlled by acetalation time. These nanomaterials with pH-modulated hydrolysis and pH-triggered drug delivery capability show good biocompatibility in vitro and in vivo. Incorporation of anticancer drug paclitaxel (PTX) into newly developed pH-sensitive nanosystems leads to nanotherapeutics with significantly improved cytotoxic activity against various tumor cells. Importantly, thus formulated nanomedicines can reverse the multidrug resistance of PTX-resistant cancer cells. In vivo antitumor studies also reveal the superior of pH-sensitive nanosystems over pristine PTX and pH-insensitive PLGA nanoformulations. Moreover, comparison with other two acid-labile materials evidenced the advantages of cyclodextrin-based nanovehicles with respect to drug loading capacity, in vitro and in vivo activity as well as alleviated adverse effects. These pH-responsive nanoparticles may serve as new generation nanocarriers for drug delivery. |
