| 論文名 |
Detection of compatibility between baclofen and excipients with aid of infrared spectroscopy and chemometry. |
| 著者 |
Barbara Rojek
Marek Wesolowski
Bogdan Suchacz
|
| キーワード |
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| 出版年月 |
1970年1月 |
| 発表先 |
Spectrochim Acta A Mol Biomol Spectrosc. 2013 Dec;116:532-8. |
| WEBサイト |
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| 論文概要（和文） |
赤外線分光法とケモメトリーを利用したバクロフェンと賦形剤間の適合性の検出。 |
| 論文概要（英文） |
In the paper infrared (IR) spectroscopy and multivariate exploration techniques: principal component analysis (PCA) and cluster analysis (CA) were applied as supportive methods for the detection of physicochemical incompatibilities between baclofen and excipients. In the course of research, the most useful rotational strategy in PCA proved to be varimax normalized, while in CA Ward's hierarchical agglomeration with Euclidean distance measure enabled to yield the most interpretable results. Chemometrical calculations confirmed the suitability of PCA and CA as the auxiliary methods for interpretation of infrared spectra in order to recognize whether compatibilities or incompatibilities between active substance and excipients occur. On the basis of IR spectra and the results of PCA and CA it was possible to demonstrate that the presence of lactose, β-cyclodextrin and meglumine in binary mixtures produce interactions with baclofen. The results were verified using differential scanning calorimetry, differential thermal analysis, thermogravimetry/differential thermogravimetry and X-ray powder diffraction analyses. |
