| 論文名 |
Determination of fluoxetine enantiomers in pharmaceutical formulations by electrokinetic chromatography-counter current technique. |
| 著者 |
Luc?a Asensi-Bernardi
Yolanda Mart?n-Biosca
Eder Fornet-Herrero
Salvador Sagrado
Mar?a Jos? Medina-Hern?ndez
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| キーワード |
|
| 出版年月 |
1970年1月 |
| 発表先 |
Biomed Chromatogr. 2013 Mar;27(3):377-81. |
| WEBサイト |
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| 論文概要（和文） |
界面動電クロマトグラフィー-カウンター電流技術による製剤中のフルオキセチン鏡像異性体の定量。 |
| 論文概要（英文） |
In this work, an electrokinetic chromatography-counter current procedure for the separation of fluoxetine enantiomers using highly sulfated β-cyclodextrin was optimized and applied to the determination of the enantiomers in three pharmaceutical formulations according to the matrix features. Quality criteria were applied to facilitate its transferability to testing laboratories. Fluoxetine was used therapeutically as the racemate, although a stereospecificity associated with its interactions with the neuronal serotonin-uptake carrier was demonstrated. In this context, the development of enantioselective methods for the chiral analysis of pharmaceuticals allowing stereoisomer ratio estimations has increasing interest in pharmaceutical industry. The proposed method allows the quantification of both enantiomers in less than 2 min with high resolution (R(s) = 2.4). |
