| 論文名 |
Efficient microwave-assisted synthetic protocols and in silico behaviour prediction of per-substituted β-cyclodextrins. |
| 著者 |
K Martina
G Cravotto
M Caporaso
L Rinaldi
C Villalonga-Barber
G Ermondi
|
| キーワード |
|
| 出版年月 |
1970年1月 |
| 発表先 |
Org Biomol Chem. 2013 Sep 7;11(33):5521-7. |
| WEBサイト |
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| 論文概要（和文） |
効率的なマイクロ波支援合成プロトコルおよび置換されたβ-シクロデキストリンのin silico挙動予測。 |
| 論文概要（英文） |
Selective per-substituted cyclodextrin design enables the carrier's physicochemical and binding properties to be tailored and can even modify some biological native structure effects. We herein report a number of highly efficient microwave-assisted synthetic protocols for the preparation of several amino, ureido and thioureido per-substituted β-cyclodextrin derivatives. A rapid parallel synthetic approach has given a set of 14 different CD derivatives. Our strategy is supported by computational analyses which were used to estimate the physicochemical behaviour of per-substituted derivatives and to tailor suitable substituents. |
