| 論文名 |
Enantioselective separation of dansyl-DL-amino acids and some racemates on "click" functionalized native α-cyclodextrin based sub-2 μm columns. |
| 著者 |
Feng Ai
Yong Wang
Hui Chen
Yanhui Yang
Timothy Thatt Yang Tan
Siu-Choon Ng
|
| キーワード |
|
| 出版年月 |
1970年1月 |
| 発表先 |
Analyst. 2013 Apr 21;138(8):2289-94. |
| WEBサイト |
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| 論文概要（和文） |
「クリック」官能化ネイティブα-シクロデキストリンベースのサブ2μmカラムでのダンシル-DL-アミノ酸といくつかのラセミ化合物のエナンチオ選択的分離。 |
| 論文概要（英文） |
The current work demonstrates that native α-cyclodextrin, anchored onto sub-2 μm silica particles via "click" reactions and packed into a 5 cm column, was found to be effective for the resolution of 11 pairs of dansyl-DL-amino acids (DAAs) using ultra-high performance liquid chromatography (UHPLC). All DAAs were completely or partially separated on the column and the resolution achieved for 7 pairs of DAAs was significantly greater than 1.5. It was found that the buffer type exerted a profound impact on the separation. The effects of analyte substituents adjacent to the chiral center of analytes as well as operation conditions with respect to the separation efficiency were discussed. Five racemic compounds with single or double rings also got resolved on this short α-CD column to some extent. |
