| 論文名 |
Encapsulation of a flavonoid-rich Allium cepa L. var. agrogatum don extract in β-cyclodextrin for transdermal drug delivery. |
| 著者 |
Zhiying Ding
Min Wu
Qiushi Guo
Xiaohong Yang
Bingren Zhang
|
| キーワード |
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| 出版年月 |
1970年1月 |
| 発表先 |
J Agric Food Chem. 2013 May 22;61(20):4914-20. |
| WEBサイト |
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| 論文概要（和文） |
経皮ドラッグデリバリーのためのβ-シクロデキストリン中のフラボノイドに富むセリウムL Var Agrogatum Don抽出物のカプセル化。 |
| 論文概要（英文） |
This work aims to evaluate the encapsulation of a flavonoid-rich Allium cepa L. var. agrogatum Don extract (ACADFE) in β-cyclodextrin (β-CD) by analyzing the percutaneous penetration in vitro and in vivo, leading to an explanation of the physical mechanism during transdermal transport. The optimal inclusion compound containing ACADFE in β-CD was prepared in a 1:3 molar ratio. The physicochemical characterization of the inclusion complex was performed using IR, UV-vis, simultaneous thermogravimetry (TG), and differential thermal analysis (DTA) studies. It was concluded that the inclusion complex could improve the aqueous solubility and bioavailability of ACADFE. The inclusion complex exhibited significant enhancement of percutaneous absorption both in vitro and in vivo. The dorsal skins of hairless mice were photographed using a confocal scanning laser microscope. Confocal scanning laser microscopy shows that penetration of the ACADFE-β-CD inclusion complex proceeds across skin via both follicular and transcellular routes. |
