| 論文名 |
Evaluation of a liquid chromatography method for quality control of methylated cyclodextrins. |
| 著者 |
L Foug?re
C Elfakir
M Lafosse
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| キーワード |
|
| 出版年月 |
1970年1月 |
| 発表先 |
J Chromatogr A. 2013 Feb 15;1277:42-7. |
| WEBサイト |
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| 論文概要（和文） |
メチル化シクロデキストリンの品質管理のための液体クロマトグラフィー法の評価。 |
| 論文概要（英文） |
Halo C18 column (fused core particles) and Chromolith RP18 column (monolith) were evaluated in liquid chromatography in order to analyze methylated-β-cyclodextrins (Me-β-CD) with various degrees of substitution, DS such as the number of methyl groups per cyclodextrin ring. Chromolith RP18 enables a performing analysis of Me-β-CD with low DS but is not suitable for dimethyl-β-cyclodextrins (DM-β-CD). On the other hand, Halo C18 column allows an improved fingerprint of CDs having a DS from 4.9 up to a value major than 14 and avoiding the use of various chromatographic systems. Thus, liquid chromatography performed with this column and an evaporative light scattering detector can be used as a generic system for methylated CD analysis. Moreover, fused core particles of Halo C18 column enables a rapid analysis and liquid chromatography coupled with electrospray-mass spectrometry appears as a powerful tool to determine co-elution and to characterize various isomers of complex methylated-β-cyclodextrin mixtures. |
