| 論文名 |
Evaluation of the effect of hydroxypropyl-β-cyclodextrin on topical administration of milk thistle extract. |
| 著者 |
Gianpiera Spada
Elisabetta Gavini
Massimo Cossu
Giovanna Rassu
Antonio Carta
Paolo Giunchedi
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| キーワード |
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| 出版年月 |
1970年1月 |
| 発表先 |
Carbohydr Polym. 2013 Jan 30;92(1):40-7. |
| WEBサイト |
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| 論文概要（和文） |
オオアザミ抽出物の局所投与に対するヒドロキシプロピル-β-シクロデキストリンの効果の評価。 |
| 論文概要（英文） |
Two water in oil emulsions composed by eudermic ingredients as glycerin, cocoa butter, almond oil and a variety of lipids, were enriched respectively with milk thistle dry extract (MT) or with a binary complex composed by MT and hydroxypropyl-β-cyclodextrin (HP) (1:4 w/w) correspondent to 1% (w/w) in sylimarine in order to obtain two different emulsions designed for the skin delivery and determine influence of hydroxypropyl-β-cyclodextrin on the extract delivery and permeation. Uv-vis spectrophotometric analyses demonstrated that phytocomplex formation influences the finding of MT after the complexation process and the in vitro antioxidant activity. Further in vitro and ex vivo experiments demonstrated that the penetration capability of MT from formulations is strictly influenced by the phytocomplex able to control MT permeation; moreover phytocomplex increases flavonoids stability during the in vitro tests. Additionally, in vivo studies showed that the penetration into the stratum corneum of the active ingredients is effectively achieved by the phytocomplex formation, in fact about 80% of MT is absorbed by the skin along 1h despite the 30% of MT not complexed absorbed during the same period. |
