| 論文名 |
Fabrication of cyclodextrin-templated mesoporous silica for improved dissolution of carbamazepine. |
| 著者 |
Ali MT
Fule R
Sav A
Amin P
|
| キーワード |
|
| 出版年月 |
1970年1月 |
| 発表先 |
Drug Deliv Transl Res. 2013 Jun;3(3):235-42. |
| WEBサイト |
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| 論文概要（和文） |
カルバマゼピンの溶解を改善するためのシクロデキストリンを鋳型としたメソポーラスシリカの作製。 |
| 論文概要（英文） |
In the present paper, preparation of mesoporous silica using hydroxy propyl-β-cyclodextrin as a template and its use in solubility enhancement of carbamazepine (CBZ) is reported. The produced mesoporous silica (MS) displayed a large surface area 480.37 m(2)/g and pore volume 0.8041 cm(3)/g. CBZ was loaded on MS and then compressed into a tablet. Dissolution kinetics studies revealed rapid release profiles in comparison to neat crystalline CBZ. Solid-state characterization was done using IR, DSC, PXRD, SEM and TEM, and nitrogen sorption studies. CBZ was found to be in non-crystalline state due to geometric confinement in the nanopore. |
