| 論文概要（英文） |
Pomolic acid (PA) is one of the pentacyclic triterpenoids, and is contained in very small amounts in plants such as apple and persimmon peels. Previously, some reports showed pharmacological properties of PA including anti-cancer, anti-diabetes and anti-obesity. Interestingly on the effects for lipid metabolism, PA suppresses the increase in the activity of glycerol-3-phosphate dehydrogenase, a neutral fat synthesis-related enzyme, whereas other pentacyclic triterpenoids such as oleanolic and ursolic acids do not show this effect. However, the high hydrophobicity is a problem of pentacyclic triterpenoids causes their low oral absorbability and bioavailability. In general, cyclodextrins (CDs) can enhance oral absorbability and bioavailability of hydrophobic compounds via formation of inclusion complex. Therefore, bioavailability of PA may be enhanced by CDs. In this study, PA-CD inclusion complexes were prepared and their structural properties were evaluated by Fourier transform infrared spectroscopy (FT-IR) and scanning electron microscope (SEM). In addition, their solubility in artificial intestinal fluid, which can be used to predict their oral absorbability, was evaluated. |
