| 論文名 |
Host-guest interaction between new nitrooxoisoaporphine and β-cyclodextrins: synthesis, electrochemical, electron spin resonance and molecular modeling studies. |
| 著者 |
P?rez-Cruz F
Aguilera-Venegas B
Lapier M
Sobarzo-S?nchez E
Uriarte Villares E
Olea-Azar C
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| キーワード |
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| 出版年月 |
1970年1月 |
| 発表先 |
Spectrochim Acta A Mol Biomol Spectrosc. 2013 Feb;102:226-34. |
| WEBサイト |
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| 論文概要（和文） |
新しいニトロオキソイソアポルフィンとβ-シクロデキストリン間のホスト-ゲスト相互作用：合成、電気化学、電子スピン共鳴および分子モデリング研究。 |
| 論文概要（英文） |
A new nitrooxoisoaporphine derivative was synthetized and characterized by cyclic voltammetry and electron spin resonance. Its aqueous solubility was improved by complexes formation with β-cyclodextrin, heptakis(2,6-di-O-methyl)-β-cyclodextrin and (2-hydroxypropyl)-β-cyclodextrin. In order to assess the inclusion degree reached by nitrooxoisoaporphine in cyclodextris cavity, the stability constants of formation of the complexes were determined by phase-solubility measurements obtaining in all cases a type-A(L) diagram. Moreover, electrochemical studies were carried out, where the observed change in the EPC value indicated a lower feasibility of the nitro group reduction. Additionally, a detailed spatial configuration is proposed for inclusion of derivate within the cyclodextrins cavity by 2D NMR techniques. Finally, these results are further interpreted by means of molecular modeling studies. Thus, theoretical results are in complete agreement with the experimental data. |
