| 論文名 |
In Vitro and In Vivo Evaluation of Oxatomide β -Cyclodextrin Inclusion Complex. |
| 著者 |
Fahima M Hashem
Mohamed Mostafa
Mahmoud Shaker
Mohamed Nasr
|
| キーワード |
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| 出版年月 |
1970年1月 |
| 発表先 |
J Pharm (Cairo). 2013;2013:629593. |
| WEBサイト |
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| 論文概要（和文） |
オキサトマイドβ-シクロデキストリン包接複合体のインビトロおよびインビボ評価。 |
| 論文概要（英文） |
The objective of this study was to evaluate the influence of oxatomide β-cyclodextrin inclusion complex on the physicochemical properties and bioavailability of the drug. Oxatomide β-cyclodextrin solid complex was prepared with equimolar ratio of both oxatomide and β-cyclodextrin in presence or absence of water soluble polymers using different techniques. The coevaporated complex prepared in presence of PVP-K15 showed a prompt drug release and significantly increased % dissolution efficiency (P < 0.05) compared to the pure oxatomide. Moreover, the results of bioavailability evaluation of this complex in rabbits compared to commercial drug product indicated a 73.15% increase in the oral bioavailability of oxatomide. In conclusion, inclusion complex of oxatomide with β-cyclodextrin prepared by coevaporation in presence of PVP-K15 not only results in an enhancement of the oxatomide dissolution rate but also improves the bioavailability of oxatomide. |
