| 論文名 |
insights into novel supramolecular complexes of two solid forms of norfloxacin and β-cyclodextrin. |
| 著者 |
Ana K Chattah
Kamal H Mroue
Laura Y Pfund
Ayyalusamy Ramamoorthy
Marcela R Longhi
Claudia Garnero
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| キーワード |
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| 出版年月 |
1970年1月 |
| 発表先 |
J Pharm Sci. 2013 Oct;102(10):3717-24. |
| WEBサイト |
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| 論文概要（和文） |
ノルフロキサシンとβ-シクロデキストリンの2つの固体形態の新しい超分子錯体への洞察。 |
| 論文概要（英文） |
The solid-state properties of novel complexes of β-cyclodextrin and two different solid forms of norfloxacin were investigated at the molecular level, in an attempt to obtain promising candidates for the preparation of alternative matrices used in pharmaceutical oral formulations. In order to evaluate the physical properties inherited from the different polymorphs, these supramolecular systems were characterized using a variety of spectroscopic techniques including natural-abundance (13) C cross-polarization magic-angle-spinning (CP-MAS) nuclear magnetic resonance (NMR), powder X-ray diffraction, and Fourier transform infrared spectroscopy. The intrinsic proton spin-lattice relaxation times detected in (13) C CP-MAS NMR spectra are used to confirm and distinguish the complex formation, as well as to provide better insights into the molecular fragments that are involved in the interaction with β-cyclodextrin. |
