| 論文名 |
Modulation in prototropism of the photosensitizer Harmane by host:guest interactions between β-cyclodextrin and surfactants. |
| 著者 |
Bijan K Paul
Debarati Ray
Aniruddha Ganguly
Nikhil Guchhait
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| キーワード |
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| 出版年月 |
1970年1月 |
| 発表先 |
J Colloid Interface Sci. 2013 Dec 1;411:230-9. |
| WEBサイト |
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| 論文概要（和文） |
ホストによる光増感剤ハルマンのプロトトロピズムの調節：β-シクロデキストリンと界面活性剤の間のゲスト相互作用。 |
| 論文概要（英文） |
The present contribution demonstrates the photophysics of a prospective cancer cell photosensitizer Harmane (HM) belonging to the family of β-carboline in mixed microheterogeneous environments of β-cyclodextrin (β-CD) and surfactants having varying surface charges using steady-state and time-resolved fluorescence spectroscopic techniques. The remarkable modulations in prototropic activities of the micelle-bound drug in the presence of β-CD evinces for disruption of the micellar structural integrity by β-CD. The results are meticulously discussed in relevance to the effect of a potential drug delivery vehicle (CD) on the membrane-mimetic micellar system. Further, application of an extrinsic fluorescence probe for monitoring such interactions is fraught by the possibilities of no less than three equilibria that can operate simultaneously viz., (i) surfactant-cyclodextrin, (ii) surfactant-fluorophore and (iii) cyclodextrin-fluorophore. This aspect highlights the enormous importance of the issue of suitability of the fluorescence probe to study such complicated systems and interaction phenomena. Also the varying interaction scenario of β-CD with the nature of the surfactant highlights the importance of precise knowledge of the strength and locus of drug binding in delineating such complex interactions. The results of the present investigation advocate for the potential applicability of the drug (HM) itself as a fluorescence reporter in study of such complex microheterogeneous interactions. |
