| 論文名 |
Multifunctional magnetic fluorescent hybrid nanoparticles as carriers for the hydrophobic anticancer drug 5-fluorouracil. |
| 著者 |
Swagatika Sahu
Sasmita Mohapatra
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| キーワード |
|
| 出版年月 |
1970年1月 |
| 発表先 |
Dalton Trans. 2013 Feb 14;42(6):2224-31. |
| WEBサイト |
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| 論文概要（和文） |
疎水性抗癌剤5-フルオロウラシルの担体としての多機能磁性蛍光ハイブリッドナノ粒子。 |
| 論文概要（英文） |
In this paper fluorescent magnetic Fe(3)O(4)@m-SiO(2)@YPO(4):Tb(3+) particles with a size of 52 nm have been prepared and characterized. The surface of the nanoparticles was modified with β-cyclodextrin and folic acid using glutathione as a linker. The hydrophobic anticancer drug 5-fluorouracil (5-FU) was successfully loaded on the fluorescent magnetic nanoparticles via formation of the 5-FU-CD inclusion complex. The overall size of the drug conjugate is 71 nm and the particles are highly stable in an aqueous medium without any deterioration of HD size. The drug conjugate favors more release at lower pH owing to instability of the 5-FU-CD inclusion complex. These results demonstrate that the developed multifunctional nanocomposite can be potentially used in magnetically guided delivery of 5-FU. |
