| 論文名 |
Multilayered structure based on poly(N,N-dimethyl-acrylamide-co-3,9-divinyl-2,4,8,10-tetraoxaspiro (5.5) undecane) prepared in a multiphase gelation process. |
| 著者 |
Aurica P Chiriac
Loredana E Nita
Manuela T Nistor
Liliana Tartau
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| キーワード |
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| 出版年月 |
1970年1月 |
| 発表先 |
Int J Pharm. 2013 Nov 1;456(1):21-30. |
| WEBサイト |
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| 論文概要（和文） |
多相ゲル化プロセスで調製したポリ（N、N-ジメチル-アクリルアミド-co-3,9-ジビニル-2,4,8,10-テトラオキサスピロ（5.5）ウンデカン）に基づく多層構造。 |
| 論文概要（英文） |
The study is devoted to the preparation of a multi-membrane gel system based on poly(N,N-dimethyl-acrylamide-co-3,9-divinyl-2,4,8,10-tetraoxaspiro (5.5) undecane) copolymer. The complex supra-structure was realized by layer by layer deposition technique, from the gel-core to the periphery by crosslinking poly(N,N-dimethyl-acrylamide-co-3,9-divinyl-2,4,8,10-tetraoxaspiro (5.5) undecane) (P(DMA-co-U)) with N,N'-methylene-bis-acrylamide and using as well β-cyclodextrin with double purpose as compound for constructing further the edge of the interfacial supramolecular assemblies and to improve the host-guest complexation of further bioactive compounds. Basic copolymer has dual thermo- and pH sensitive character. The multi-membrane 'onion-like' gel system was tested as matrix for embedding Norfloxacin. Hematologic, biochemical, immunologic studies used to determine the biocompatibility of multi-membrane gel structures loaded with drug that directly contact living tissue provided a reasonable assessment of safety as implants. Histopathologic exams did not reveal any disturbances of the normal liver architecture in animals with multi-membrane gel system containing Norfloxacin compared to control group with sterile cotton pellets implant. Good biocompatibility for the implants based on multi-membrane gel structures loaded with drug were achieved from the in vivo tests these suggesting that biomaterials may be suitable for in vivo use as a local drug delivery system. |
