| 論文名 |
Multivalent glycoliposomes and micelles to study carbohydrate-protein and carbohydrate-carbohydrate interactions. |
| 著者 |
Narayanaswamy Jayaraman
Krishnagopal Maiti
Kottari Naresh
|
| キーワード |
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| 出版年月 |
1970年1月 |
| 発表先 |
Chem Soc Rev. 2013 Jun 7;42(11):4640-56. |
| WEBサイト |
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| 論文概要（和文） |
炭水化物-タンパク質および炭水化物-炭水化物相互作用を研究するための多価糖リポソームおよびミセル。 |
| 論文概要（英文） |
This tutorial review describes multivalent carbohydrate-protein and carbohydrate-carbohydrate interaction studies that utilize self-assembled aggregates of thermodynamically stable liposomes and micelles. Strategies to prepare multivalent glycoliposomes and micelles include: (i) insertion of synthetic glycolipids into matrix lipids; (ii) preparation of glycolipids that aggregate to liposomes and micelles and (iii) modification of the hydrophilic surfaces with desired sugars. Several design strategies have been developed in order to obtain constituent glycolipids, having multivalent sugar moieties and their subsequent interactions with proteins were assessed in relation to the type of linkers that connect the hydrophilic and lipophilic segments. Lipophilic segments other than alkyl chains have also been developed. Polymer based glycoliposomes and micelles form an emphasis. Further, glycoliposomes facilitate studies of carbohydrate-carbohydrate interactions. An overview of the various types of glycoliposomes and micelles used to study carbohydrate-protein and carbohydrate-carbohydrate recognition phenomena is presented. |
