| 論文名 |
Nanoceria-triggered synergetic drug release based on CeO(2) -capped mesoporous silica host-guest interactions and switchable enzymatic activity and cellular effects of CeO(2). |
| 著者 |
Can Xu
Youhui Lin
Jiasi Wang
Li Wu
Weili Wei
Jinsong Ren
Xiaogang Qu
|
| キーワード |
|
| 出版年月 |
1970年1月 |
| 発表先 |
Adv Healthc Mater. 2013 Dec;2(12):1591-9. |
| WEBサイト |
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| 論文概要（和文） |
CeO（2）に基づくNanoceriaトリガーの相乗的薬物放出-キャップ付きメソポーラスシリカホスト-ゲスト相互作用および切り替え可能な酵素活性とCeO（2）の細胞効果。 |
| 論文概要（英文） |
Herein, a pH stimuli-responsive vehicle for intracellular drug delivery using CeO2 capped mesoporous silica nanoparticles (MSN) is reported. β-Cyclodextrin-modified CeO2 nanoparticles could cap onto ferrocene-functionalized mesoporous silica through host-guest interactions. After internalization into A549 cells by a lysosomal pathway, the ferrocenyl moieties are oxidized to ferrocenium ions by CeO2 lids, which could trigger the uncapping of the CeO2 and cause the drugs release. Because of the pH-dependent toxicity, the CeO2 here behaves as a multi-purpose entity that not only acts as a lid but also exhibits a synergistic antitumor effect on cancer cells. Meanwhile, the cell protective effect of CeO2 nanoparticles alone is demonstrated, which ensures that the dissolved CeO2 nanoparticles can be non-toxic to normal cells. |
