| 論文名 |
Nanoencapsulation of quercetin and resveratrol into elastic liposomes. |
| 著者 |
Pabyton G Cadena
Marcela A Pereira
Rafaela B S Cordeiro
Isabella M F Cavalcanti
Ben?cio Barros Neto
Maria do Carmo C B Pimentel
Jos? Luiz Lima Filho
Valdinete L Silva
Nereide S Santos-Magalh?es
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| キーワード |
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| 出版年月 |
1970年1月 |
| 発表先 |
Biochim Biophys Acta. 2013 Feb;1828(2):309-16. |
| WEBサイト |
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| 論文概要（和文） |
弾性リポソームへのケルセチンとレスベラトロールのナノカプセル化。 |
| 論文概要（英文） |
Based on the fact that quercetin (QUE) and resveratrol (RES) induce a synergic inhibition of the adipogenesis and increase apoptosis in adipocytes, and that sodium deoxycholate (SDC) has necrotic effects, the nanoencapsulation of QUE and RES into SDC-elastic liposomes is proposed as a new approach for dissolving the subcutaneous fat. The concentration of constituents and the effect of the drug incorporation into cyclodextrin inclusion complexes on the stability of QUE/RES-loaded liposomes were studied. The best liposomal formulation reduced the use of phosphatidylcholine and cholesterol in 17.7% and 68.4%, respectively. Liposomes presented a mean diameter of 149nm with a polydispersion index of 0.3. The zeta potential of liposomes was slightly negative (-13.3mV) due to the presence of SDC in the phospholipid bilayer. Encapsulation efficiency of QUE and RES into liposomes was almost 97%. To summarize, QUE/RES-loaded elastic liposomes are stable and suitable for subcutaneous injection, thereby providing a new strategy for reducing subcutaneous fat. |
