| 論文名 |
New chemodosimetric probe for the specific detection of Hg2+ in physiological condition and its utilisation for cell imaging studies. |
| 著者 |
Sukdeb Saha
Hridesh Agarwalla
Hariom Gupta
Mithu Baidya
E Suresh
Sudip K Ghosh
Amitava Das
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| キーワード |
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| 出版年月 |
1970年1月 |
| 発表先 |
Dalton Trans. 2013 Nov 14;42(42):15097-105. |
| WEBサイト |
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| 論文概要（和文） |
生理学的条件におけるHg2 +の特異的検出のための新しいケモドシメトリックプローブとその細胞イメージング研究への利用。 |
| 論文概要（英文） |
A dithiane derivative of BODIPY is synthesized. This new reagent could be used for the specific and instantaneous detection of Hg(2+) in physiological condition. This dithiane reagent reacts specifically with Hg(2+) to regenerate the parent BODIPY-aldehyde with consequential change in visually detectable optical responses and this provides the possibility of using this reagent as a colorimetric probe or as a fluorescent biomarker/imaging reagent. Further, non-covalent interactions could be utilized for formation of an inclusion complex with biologically benign β-cyclodextrin for enhancing its solubility in aqueous environment and this included adduct could be used as a fluorescent marker and imaging reagent for Hg(2+). Uptake of Hg(2+) ions in live HeLa cells, exposed to a solution having Hg(2+) ion concentration as low as 2 ppb, could also be detected by confocal laser microscopic studies. |
