| 論文名 |
New cyclodextrin derivative containing poly(L-lysine) dendrons for gene and drug co-delivery. |
| 著者 |
Dong Ma
Hong-Bin Zhang
Yu-Yun Chen
Jian-Tao Lin
Li-Ming Zhang
|
| キーワード |
|
| 出版年月 |
1970年1月 |
| 発表先 |
J Colloid Interface Sci. 2013 Sep 1;405:305-11. |
| WEBサイト |
|
| 論文概要（和文） |
遺伝子と薬物の共送達のためのポリ（L-リジン）デンドロンを含む新しいシクロデキストリン誘導体。 |
| 論文概要（英文） |
To develop a multifunctional polymeric carrier for gene and drug co-delivery, a new cyclodextrin derivative containing poly(L-lysine) dendrons was prepared by the click conjugation of per-6-azido-β-cyclodextrin with propargyl focal point poly(L-lysine) dendron of third generation and then characterized by FTIR, (1)H NMR, and GPC analyses. It was found that such a conjugate could form colloidally stable nanocomplexes with plasmid DNA in aqueous system and exhibited high gene transfection efficiency. Moreover, it could load efficiently methotrexate drug with anticancer activity and showed a sustained release behavior. Different from commonly used amphiphilic copolymers with cationic character, the as obtained cyclodextrin derivative may be used directly for the combinatorial delivery of nucleic acid and lipophilic anticancer drugs without a complicated micellization process. |
