| 論文名 |
New star-shaped carriers composed of β-cyclodextrin cores and disulfide-linked poly(glycidyl methacrylate) derivative arms with plentiful flanking secondary amine and hydroxyl groups for highly efficient gene delivery. |
| 著者 |
Y Hu
Y Zhu
W T Yang
F J Xu
|
| キーワード |
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| 出版年月 |
1970年1月 |
| 発表先 |
ACS Appl Mater Interfaces. 2013 Feb;5(3):703-12. |
| WEBサイト |
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| 論文概要（和文） |
β-シクロデキストリンコアとジスルフィド結合ポリ（メタクリル酸グリシジル）誘導体アームで構成された新しい星型キャリアは、高効率の遺伝子送達のための豊富な隣接第二アミン基とヒドロキシル基を備えています。 |
| 論文概要（英文） |
The biocleavable star-shaped vectors (CD-SS-PGEAs) consisting of nonionic β-cyclodextrin (β-CD) cores and disulfide-linked low-molecular-weight poly(glycidyl methacrylate) (PGMA) derivative arms with plentiful flanking secondary amine and hydroxyl groups were successfully proposed for highly efficient gene delivery. A simple two-step method was first adopted to introduce reduction-sensitive disulfide-linked initiation sites of atom transfer radical polymerization (ATRP) onto β-CD cores. The disulfide-linked PGMA arms prepared subsequently via ATRP were functionalized via the ring-opening reaction with ethanolamine (EA) to produce the cationic EA-functionalized PGMA (PGEA) arms with plentiful secondary amine and nonionic hydroxyl units. The cationic PGEA arms can be readily cleavable from the β-CD cores under reducible conditions. Such biocleavable star-shaped CD-SS-PGEA vectors possessed the good pDNA condensation ability, low cytotoxicity, and efficient gene delivery ability. |
