| 論文名 |
Nonaqueous capillary electrophoretic enantioseparation of water insoluble Tr?ger's base derivatives using β-cyclodextrin as chiral selector. |
| 著者 |
Pavel Rezanka
David S?kora
Michal Novotn?
Martin Havl?k
Vladim?r Kr?l
|
| キーワード |
|
| 出版年月 |
1970年1月 |
| 発表先 |
Chirality. 2013 Nov;25(11):810-3. |
| WEBサイト |
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| 論文概要（和文） |
β-シクロデキストリンをキラルセレクターとして用いた水不溶性トレゲル塩基誘導体の非水キャピラリー電気泳動エナンチオ分離。 |
| 論文概要（英文） |
Racemic mixtures of six Tr?ger's base derivatives were separated by chiral nonaqueous capillary electrophoresis. The separation protocol was optimized first for suitable solvents. Then the applicability of various salts dissolved in organic solvents and their mixtures was evaluated. As chiral selectors β-cyclodextrin and heptakis(2,6-di-O-methyl)-β-cyclodextrin at various concentrations were used. The best enantioselectivity for the studied analytes was obtained utilizing formamide as organic nonaqueous solvent containing a mixture of sodium citrate and tris(hydroxymethyl)aminomethane acetate as electrolytes, and β-cyclodextrin as chiral additive. The experimental results demonstrated the feasibility of nonaqueous capillary electrophoresis for enantioseparation of Tr?ger's base derivatives. This technique represents a suitable alternative to more commonly used capillary electrophoresis in aqueous environment. |
