| 論文名 |
On-line enantioseparation of chlorpheniramine using β-cyclodextrin and carbon nanotubes after multivariate optimization. |
| 著者 |
Gimena Acosta
Ra?l Silva
Ra?l A Gil
Roxana Gomez
Liliana P Fern?ndez
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| キーワード |
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| 出版年月 |
1970年1月 |
| 発表先 |
Talanta. 2013 Feb 15;105:167-72. |
| WEBサイト |
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| 論文概要（和文） |
多変量最適化後のβ-シクロデキストリンとカーボンナノチューブを使用したクロルフェニラミンのオンラインエナンチオ分離。 |
| 論文概要（英文） |
Multiwalled carbon nanotubes are evaluated here as solid phase extraction (SPE) sorbent aiming to (±)-chlorpheniramine (CPA) enantioresolution with fluorimetric detection. β-cyclodextrin (CD) was added to the racemate and solutions with HCl and sodium dodecyl sulfate (SDS) in different proportions were assayed as eluents to achieve the separation between both enantiomers. The overall methodology involved a flow injection (FI) strategy enabling high sample throughput and low reagents consumption making it suitable for drug routine quality control. An adequate enantioresolution (2.08) with satisfactory responses for both (R)-CPA (peak area=285) and (S)-CPA (peak area=380) was achieved applying the proposed FI-SPE strategy under the optimized conditions [β-CD] = 1.0 mmol L(-1), [HCl] = 1.0 × 10(-2) mol L(-1), [SDS] = 4.0 × 10(-4) mol L(-1) and eluent flow rate = 8.0 rpm. |
