| 論文名 |
Opposing effects of dexamethasone, agrin and sugammadex on functional innervation and constitutive secretion of IL-6 in in vitro innervated primary human muscle cells. |
| 著者 |
K Rezonja
P Lorenzon
T Mars
|
| キーワード |
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| 出版年月 |
1970年1月 |
| 発表先 |
Neurosci Lett. 2013 Aug 9;549:186-90. |
| WEBサイト |
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| 論文概要（和文） |
デキサメタゾン、アグリン、スガマデックスの機能的神経支配および体外神経支配された一次ヒト筋細胞におけるIL-6の構成的分泌に対する反対の効果。 |
| 論文概要（英文） |
Neuromuscular junction development is the key process required for successful neuromuscular transmission and functional innervation of skeletal muscle fibres. Various substances can influence these processes, some of which are in common use in clinical practice. In the present study, the effects of the potentially new therapeutic agent agrin were followed, along with the widely used glucocorticoid dexamethasone. The in vitro experimental model used was functional innervation and constitutive interleukin 6 (IL-6) secretion of human muscle cells. Additionally, the selective relaxant binding agent sugammadex and its possible interaction with dexamethasone were followed. Dexamethasone impaired functional innervation while agrin had opposing effects. Furthermore, based on interference with IL-6 secretion, we show potential (chemical) interactions between dexamethasone and sugammadex. The physiological effects of this interaction should be taken into consideration under clinical conditions where these two drugs might be applied simultaneously. |
