| 論文名 |
Pharmacokinetic delivery and metabolizing rate of nicardipine incorporated in hydrophilic and hydrophobic cyclodextrins using two-compartment mathematical model. |
| 著者 |
Sergey Shityakov
Carola F?rster
|
| キーワード |
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| 出版年月 |
1970年1月 |
| 発表先 |
ScientificWorldJournal. 2013 Dec 3;2013:131358. |
| WEBサイト |
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| 論文概要（和文） |
2コンパートメント数学モデルを使用して親水性および疎水性シクロデキストリンに組み込まれたニカルジピンの薬物動態学的送達および代謝率。 |
| 論文概要（英文） |
The dispersion routes of cyclodextrin complexes with nicardipine (NC), such as hydrophilic hydroxypropyl-β-cyclodextrin (NC/HPβCD) and hydrophobic triacetyl-β-cyclodextrin (NC/TAβCD), through the body for controlled drug delivery and sustained release have been examined. The two-compartment pharmacokinetic model described the mechanisms of how the human body handles with ingestion of NC-cyclodextrin complexes in gastrointestinal tract (GI), distribution in plasma, and their metabolism in the liver. The model showed that drug bioavailability was significantly improved after oral administration of cyclodextrin complexes. The mathematical significance of this study to predict nicardipine delivery using pharmacokinetic two-compartment mathematical model with linear ordinary differential equations (ODE) approach represents a valuable tool to emphasize its effectiveness and metabolizing rate and diminish the side effects. |
