No. 75 Defining a mechanism of selective decreasing effect on serum saturated fatty acids by α-CD supplementation
This research was done through collaboration with Kobe University and reported in the joint conference of 8th Asian Cyclodextrin Conference and 32th Cyclodextrin Symposium (Kumamoto, May 14~16, 2015).
Background
Our company has an attract attention technology in functional food and personal care fields which raises the water solubility, stability and bioavailability of functional ingredients by using the inclusion property of cyclodextrin (CD).
Because of its high water solubility and non-digestible property, α-CD can be taken as a water-soluble dietary fiber. Indeed, daily feed intake of α-CD shows some anti-metabolic syndrome effects, improvements of the intestinal environment and anti-allergy effect. We also reported some interesting results supporting those effects (* please refer to the newest result of research "16th", "42th", "44th" and "50th" of our homepage for details.).
In this study, we report a new knowledge of α-CD function on the mechanism of selective decreasing effect on serum saturated fatty acids by α-CD supplementation.
Functions of α-CD (human trial)
- Anti-metabolic syndrome
Lowering effect of fat and cholesterol
Inhibition effect against an elevation in blood glucose level - Regulation of intestinal functions
- Anti-allergy
Atopic dermatitis, Cedar pollen allergy, Asthma
Selective decreasing effect on serum saturated fatty acids by α-CD supplementation.
Experiment
The effects of α-CD to solubilities of fatty acids in fed-state simulated intestinal fluid (FeSSIF) were explored.
Fatty acids
Result 1. Precipitation effect of α-CD from the FeSSIF including fatty acid.
Figure 1
The precipitate was generated from the sample containing fatty acid and α-CD.
Result 2. Decreasing effects of α-CD on the fatty acid solubility (saturated vs unsaturated)
Figure 2
α-CD decreased the solubility of saturated fatty acid (C18:0) more effectively than that of unsaturated fatty acids (cis-C18:1, C18:2).
Discussion
It is well known that absorption of fatty acids is achieved by dissolving in the small intestinal fluid.
So, from these results, α-CD has a possibility on the selective absorption of fatty acids relates by the decreasing of the solubilities of fatty acids in the small intestinal fluid.
→ In the present study, one of the mechanisms of selective decreasing effect on serum saturated fatty acids by α-CD supplementation was clarified.